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Cardiology - Effects of impaired glucose metabolism on hemorheological parameters and platelet aggregation Supervisor: KOLTAI, Katalin Rheological factors and increased platelet aggregation are convincingly implicated in the development of micro- and macrovascular diseases associated with diabetes mellitus.

Glycemic control seems to be a major factor to determine the hemorheological consequences of diabetes.

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Positive associations have been found between parameters of glycemic control, fibrinogen levels and red blood cell aggregation; fibrinogen levels are also correlated to insulin resistance. The binding of fibrinogen to the GP IIb-IIIa receptor is increased in diabetic patients; and they also have a higher ratio of platelets expressing activation-dependent adhesion molecules such as activated GPIIb-IIIa, lysosomal Gp53, thrombospondin and P-selectin; plasma fibrinogen levels are also increased in diabetes.

Diabetes Almost a year before the interview, László complained of discomfort and visited his family doctor, who measured a very high blood pressure ofand then prescribed him anti-hypertension medication. After a similar malaise two months later, his test also produced a remarkably high blood sugar result. By this time László was already struggling with more serious vision problems. Medicinal mushrooms and C-Peptide gave him back hope and a chance to soon be able to take his herd to graze in the fields again; under his supervision.

Platelets may interact with glycosylated low density lipoproteins, von Willebrand factor or immune complexes, and platelet turnover may be shortened in diabetes, thereby contributing to the observation that antiplatelet agents such as aspirin and clopidogrel have a diminished effect in these patients. We aim to study the effects of impaired glucose metabolism on hemorheological parameters, platelet activation and aggregation in patients treated with different antidiabetic regimens.

TÓTH, András Chronobiology is the scientific discipline concerned with the definition, mechanisms, and significance of the so-called time structure of life forms.

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Seasonal variations in death rates with the highest levels occurring during the colder winter months have been described in many countries. Cardiovascular disease related deaths account for the majority of excess winter deaths. Circannual rhythms have been described in parameters as fibrinogen, hematocrit, platelet count, hormones, serum lipids, and glucose.

We aim to investigate whether hemorheological parameters and platelet aggregabiliy show seasonal differences in a population with established vascular disease.

In the study, adults ages 85 and over who were infected with cytomegalovirus were about twice as likely to have Type 2 diabetes compared with those not infected. Cytomegalovirus is a type of herpes virus found in 50 to 80 percent of adults over age 40; most people experience no symptoms of the infection. The findings suggest that cytomegalovirus infection plays a role in the development of Type 2 diabetes in the elderly, the researchers said. However, the study found an association, not a cause-effect link. While the findings are interesting, researchers need studies that follow people forward in time to find out whether the virus could cause Type 2 diabetes, said Dr.

We plan to investigate a possible association with certain meteorological factors as ambient temperature, daily amount of sunshine hours, relative humidity and simultaneous changes in air pressure. Cardiology - Erythrocyte deformability measurements with ektacytometry.

Methodical pitfalls.

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Ektacytometry is used to describe erythrocyte deformability. It measures the extent of deformation that various known stresses cause to cells. Results are not only affected by the physical properties of the intact cells but may be biased by changes due to manipulation with the cells and measurement circumstances as well.

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The study aims to uncover methodical pitfalls. We aim to set up measurement standards where bias of results is minimal.

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We also seek transformation methods to make results of measurements performed among different circumstances comparable. Cardiology - Hemorheological aspects of hematological malignancies Co-supervisor: Dr. RÁBAI, Miklós Hematological malignancies are accompanied with the clonal overproliferation of a blood component and the suppression of others.

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The composition of blood may be drastically different from the healthy one that may lead to diabetes caused by high blood pressure medication and microcirculatory consequences. Therapeutic methods aim to reduce pathologically high cell numbers and substitute scarce ones. We aim to study the hemorheological consequence of the diseases and applied therapies.

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We investigate what support hemorheological methods may provide to assess the risk for certain complications, the effectiveness of therapy or to schedule therapy. Cardiology - Hemorheological changes in endocrine disorders Co-supervisor: Dr. In patients with hypothyroidism we experience increased bleeding risk, in hyperthyroidism we see the elevation of the incidence of thromboembolic events. An other common endocrine disorder which is accompanied by obviously increased risk for cardiovascular death is the exogenous and endogenous glucocorticoid overproduction.

Our study wishes to investigate the non-genomic effect of thyroid hormones on platelet aggregation, and the in vitro effect of glucocorticoids on rheological parameters in healthy volunteers.

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Cardiology - Hemorheological parameters and tissue oxygen tension in peripheral artery disease Co-supervisor: Dr. Until now the medical care of PAD has been in the background compared to coronary artery disease CAD or cerebrovascular disease, despite that the number of limb amputation is times higher compared to Western-Europe, meaning that most of these procedures can be prevented.

In our study we measure tissue oxygen tension and hemorheological parameters in PAD and also monitor their changes during treatment in order to find the most effective therapy. In the low-industrialised regions IHD is the 4th, while in the medium to high-industrialised countries it is the 1st most common cause of deaths, thus its early diagnosis is essential. It is able to visualise the lumen and wall of the coronary vessels and the structure of the heart.

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In this topic we examine the changes of hemorheological parameters in different stages of coronary artery disease. VÉKÁSI, Judit Diabetic angiopathy is one of the late consequence of diabetes mellitus, which affects both small microangiopathy and large vessels macroangiopathy.

Diabetic macroangiopathy results in faster atherogenesis diabetes caused by high blood pressure medication arteriolosclerosis and atherosclerosis appears more rapidly. Diabetic microangiopathy has three forms: neuropathy, nephropathy and retinopathy. Diabetic retinopathy is the 1st or 2nd most common cause of blindness in the developed world, its presence may be detected after 15 years of diabetes mellitus.

Our aim is to screen patients suffering from diabetic retinopathy for silent — but instrumentally detectable — peripheral artery disease.

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The screening includes hemorheological and oxygen tissue tension measurements. Cardiology - Hemorheological parameters in peripheral vasospastic disorders Supervisor: KÉSMÁRKY, Gábor Peripheral vasospastic disorders are episodic, painful attacks of the acral parts caused by vércukor emelkedés okai local, diminished blood supply.

During angiology consultation blood will be taken from patients suffering from peripheral vasospastic disorders.

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