Whereas type 1 diabetes is caused by an autoimmune response directed against the insulin-producing beta islet cells of the pancreas, type 2 diabetes is caused by exhausting those beta cells through excessive energy consumption.
Essentially, if one eats too much and has high blood glucose levels, the beta cells have to produce more and more insulin to keep up, eventually leading to accumulation of damage and death. This state is referred to as insulin resistance, and it is considered to be a major contributor to the further development of type 2 diabetes. A major problem encountered by scientists seeking to study obesity and diabetes is that treatments developed in mice have failed to have any impact on humans, underlying their limited utility as a model organism for the disease.
Given this stumbling block, researchers have increasingly begun to study other animals, as in a recent paper that focused on grizzly bears. During the months leading up to hibernation, they are capable of doubling their levels of body fat. Such massive weight gain would result in serious health problems for humans, but bears are capable of tolerating these fluctuations, leading the authors to investigate how exactly this was possible.
It found that type 2 diabetes is associated with a higher risk of mortality in hospitalised COVID patients than type 1 diabetes.
As it turns out, bears are capable of uniquely regulating type 2 diabetes treatment protein called PTEN phosphatase and tensin homologwhich has a role in shutting off insulin signaling among other things. During the fall, while bears are bulking up, they turn off PTEN, which results in increased insulin sensitivity and stable blood sugar levels despite weight gain. While hibernating, PTEN is turned back on, making the bears more insulin resistant and slowing weight loss during their long winter snooze.
Go to: References 1. Prediabetes: a high-risk state for diabetes development. Diabetes Prevention Program Research Group The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the diabetes prevention program. Diabet Med.
These findings with PTEN actually mirror a previous study in humans, in which patients who only had one copy of PTEN instead of two were more resistant to complications associated with weight gain, namely diabetes and heart disease.
So all we have to do is turn off PTEN in people and their type 2 diabetes will go away, right?
- Mammut cukorbetegközpont
- Она понимала, что это больше не имеет значения: Хейл и без того знал все, что можно было знать.
- Самопроизвольный взрыв? - ужаснулась Соши.
- Do Grizzly Bears Contain the Cure for Diabetes? — The PhDISH
- Diabetes type 2 guideline
- Я тоже хотел бы с ней покувыркаться.
Remember how PTEN does more than simply shutting down insulin signaling? Well, one of those things is kind of important: It prevents cancer.
Reversing Type 2 diabetes starts with ignoring the guidelines - Sarah Hallberg - TEDxPurdueU
PTEN is an essential tumor suppressor that has been implicated in dozens of malignancies. Indeed, those patients who lacked one copy of PTEN were found to develop aggressive cancers at a much higher rate than normal.
Though this may be potentially circumvented by targeting PTEN in fat type 2 diabetes treatment only, it is still obviously a major concern for therapeutic development. While diabetes is certainly a cause of reduced quality of life, making patients more insulin sensitive will also result in increased weight gain.
Megvalósítása során alapvető fontosságú a beteg és a kezelést végző orvos, illetve segítőtársai dietetikus, diabetológiai szakápolók közötti tartós együttműködés, a folyamatos betegedukáció, továbbá a korszerű inzulinok, penek, glükométerek elérhetősége. A humán inzulinnal felépített bázis-bolus kezelési rendszer előnyt jelent a kétszeri premix inzulinnal folytatott, konzervatív inzulinterápiához viszonyítva.
Since the obesity epidemic shows no signs of slackingaddressing the associated comorbidities is a major priority for biomedical researchers. And while this research is certainly promising, there are significant barriers that need to be overcome before a drug can even begin to be conceptualized.